• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Piston plug (510) having a cylindrical body (511) having a front axial side closed by a front wall (513), said hollow cylindrical body (511) having an outer surface provided with at least one secondary sealing profile ( 610), said front wall (513) having an axial front external surface (631) provided with a coating (635), advantageously an ethylene tetrafluoroethylene film, said front wall (513) having on its radially outer edge a profile of primary seal (630), said front wall (513) and said cylindrical body (511) being made of different materials, said hollow cylindrical body (511) being overmolded on said front wall (513).
    公开号:FR3032123A1
    申请号:FR1550678
    申请日:2015-01-29
    公开日:2016-08-05
    发明作者:Mickael Swal；Ghislain Fournier
    申请人:Aptar Stelmi SAS；
    IPC主号:
    专利说明:

    [0001] The present invention relates to a syringe plunger stopper. The syringe plunger stopper is well known in the state of the art. Before actuating the syringe, it fulfills the function of a cap by isolating the fluid contained in the syringe body, and upon actuation it is transformed into a piston by pushing the fluid product out of the syringe body, generally through a needle. Generally, the syringe device comprises an actuator, such as a piston rod, which cooperates with said piston stopper to move it into the syringe body upon actuation. This plug-piston must therefore ensure tightness and is therefore generally made of rubber or other similar elastomer. A disadvantage with this type of material concerns the risks of interactions between the material of the piston stopper and the fluid product to be dispensed, in particular during the storage phase, these interactions being able to alter said fluid product. To limit these risks of interactions, it has been proposed to coat the front surface of the piston stopper, that is to say the surface in contact with the fluid during storage and during the dispensing of the product, with a coating. appropriate. It has thus been proposed in particular to have a thin film of ETFE (ethylene tetrafluoroethylene) on the front surface of the plug-piston. This implementation makes it possible to limit the risks of interactions between the material of the piston stopper and the fluid product. The application of said film however makes the manufacturing process more complex, and imposes a cutting area of the plug-piston after molding which is not optimal. In addition, the presence of this coating on the front surface stiffens the latter, and can therefore make the assembly and movement of the piston stopper in the syringe body more difficult. More specifically, the presence of this front coating decreases the deformation capacity of the front surface of the piston cap and can therefore make insertion and sliding in the syringe body more difficult. There is therefore the problem of finding the right compromise between a sufficient seal for the plug-piston once inserted into the syringe body and a process of assembly and actuation that is not too complicated or difficult.
    [0002] Moreover, the cooperation between the piston plug and the actuating member, generally a piston rod, can be done generally via a thread provided on the internal surface of the piston plug and which cooperates with a corresponding thread arranged on the front end of the piston rod. This implementation also complicates the manufacture of the piston plug, in particular the demolding phase, because of the large undercuts of the piston plug manufacturing mold required to mold the thread. The documents WO2006021380, EP1180377, EP1674121, DE10006560 and WO002092312 describe devices of the state of the art. PCT / FR2014 / 052540 discloses a syringe plunger plug similar to that of the present invention. The present invention aims to provide a piston stopper which does not reproduce the aforementioned drawbacks. In particular, the object of the present invention is to provide a piston stopper which guarantees a perfect seal during storage and during actuation, while allowing a manufacturing method, an assembly method and a simplified and reliable operation.
    [0003] The present invention also aims to provide a piston-plug which is simpler and therefore less expensive to manufacture and assemble, especially in the molding process of said piston cap. The present invention therefore relates to a piston stopper comprising a cylindrical body having an axial front end closed by a front wall, said piston stopper comprising an outer surface provided with at least one secondary sealing profile, said front wall comprising a front axial outer surface provided with a coating, preferably an ethylene tetrafluoroethylene film, said front wall having on its radially outer edge a primary sealing profile, said front wall and said cylindrical body being made of different materials, said body hollow cylindrical being overmolded on said front wall.
    [0004] Advantageously, said cylindrical body is made of a rubber material, comprising by one or more synthetic polymeric elastomers, such as butyl rubber, chlorobutyl rubber, bromobutyl rubber, copolymers of isobutylene and para-methylstyrene rubber, rubber isoprene, SBR rubber, NBR, EPDM. Advantageously, said material is associated with at least one accelerator and / or charge. Advantageously, said front wall is made of a rubber material, comprising one or more synthetic polymeric elastomers, such as butyl rubber, chlorobutyl rubber, bromobutyl rubber, copolymers of isobutylene and para-methylstyrene rubber, rubber isoprene, SBR rubber, NBR, EPDM.
    [0005] Advantageously, said material is associated with at least one accelerator and / or charge. Advantageously, said at least one accelerator and / or load of said cylindrical body is different, in quantity and / or in composition, from said at least one accelerator and / or load of said front wall.
    [0006] Advantageously, said cylindrical body comprises a secondary sealing profile and said front wall comprises a secondary sealing profile. Advantageously, said secondary sealing profiles are radially projecting beads.
    [0007] Advantageously, said front axial outer surface of said front wall comprises a deformation profile disposed radially inside said primary sealing profile of said front wall, said deformation profile being adapted to deform radially to facilitate insertion and / or or sliding said plug-piston into a syringe body.
    [0008] Advantageously, said deformation profile is made in the form of a peripheral groove formed in said front axial outer surface of said front wall, said groove being advantageously V-shaped or U-shaped. Advantageously, said cylindrical body is hollow and defines a internal volume, said hollow cylindrical body having an axially open rear axial side opposite said front axial side closed by said front wall. Advantageously, said internal volume cooperates with an actuating member of a syringe device. Advantageously, said hollow cylindrical body has on its inner surface a thread adapted to be screwed on a thread of said actuating member. Advantageously, said front axial outer surface is conical and defines a central axial point. Advantageously, said deformation profile is of rounded shape, so that said front axial outer surface of said front wall is devoid of sharp angles. These and other features and advantages of the present invention will appear more clearly in the following detailed description, with reference to the accompanying drawings, given by way of non-limiting examples, and in which: FIG. 1 is a view schematic in cross section of a plug-piston according to the state of the art, Figure 2 is a view similar to that of Figure 1, illustrating a plug-piston according to an advantageous embodiment of the present invention, Figures 3 and 4 schematically illustrate the molding step of the manufacturing method according to the state of the art of the plug-piston of FIG. 1, respectively with the closed and open mold. FIG. 5 schematically illustrates the step of cutting the process. FIGS. 6 to 11 schematically illustrate the molding and cutting steps of the manufacturing process, according to the state of the art of the piston stopper of FIG. according to an advantageous embodiment of the invention of the plug-piston of Figure 2. Figure 1 shows a piston-plug according to the state of the art, in particular as described in the co-pending patent application PCT / FR2014 / 052540. The piston plug 10, molded from a piece of elastomer, rubber or any other suitable material, comprises a cylindrical body 11, preferably hollow. This hollow cylindrical body comprises an open rear axial side 12 and a front axial side which is closed by a front wall 13. Thus, this implementation defines a piston plug 10 of generally cylindrical shape with an internal blind volume 15, that is, open on one side and closed on the other side. The front wall 13 defines a frontal axial outer surface 131 which is the surface that will be in contact with the fluid when the piston cap 10 is assembled in a syringe body (not shown) for containing such a fluid product. This axial front external surface 131 is provided with a coating 135, advantageously a thin film made of ETFE (ethylene tetrafluoroethylene), in order to limit as much as possible the interactions between said fluid product and the material of said piston stopper. Other types of suitable coatings are also conceivable, as regards the method of application of the coating as the material constituting said coating. This frontal axial outer surface 131 may be conical by defining an axial point 1310, as visible in the embodiment of Figure 1, but it could also be flat and substantially perpendicular to the central axis of the piston cap. The outer surface of the hollow cylindrical body 11 comprises at least one, preferably several sealing profiles 110, which are generally made in the form of radially projecting beads. Preferably, as shown in Figure 1, the outer surface of the hollow cylindrical body 11 comprises two sealing profiles 110 made in the form of radially projecting beads. The front wall 13 may also include a sealing profile 130 formed on its radially outer edge.
    [0009] Advantageously, said front axial outer surface 131 of said front wall 13 may comprise a deformation profile 133 which is adapted to deform to facilitate insertion of the piston plug 10 into a syringe body. This deformation profile may be arranged radially inside said sealing profile 130, that is to say that it is not necessarily disposed at the radially outer edge of said front wall 13. Advantageously, this deformation profile 133 can be produced in the form of a peripheral groove formed in said front axial axial surface 131. In the example shown in FIG. 1, this groove, before deformation, is substantially U-shaped, but it could obviously also have another shape, for example a V-shape, W or any other suitable form for radial deformation of the front wall 13 during the insertion of the piston-plug. Advantageously, said deformation profile 133 is of rounded shape, that is to say that it does not define a sharp angle in said front axial axial surface 131 of said front wall 13. However, such sharp angles can generate areas of weakness of the coating 135, not only during the molding of the plug-piston where they can be torn generator, but also in use, where the coating 135 could crack or tear at said sharp angles, by example during the compression of the plug-piston during its introduction into the syringe, with consequent risks of discontinuity of said coating. Advantageously, said coating 135 extends not only on said front axial outer surface 131, but also at least partially on the outer cylindrical surface of said sealing profile 130. This ensures the presence of a first cylindrical sealing zone between the inside of a syringe body and the coated portion of said sealing profile 130 of the piston-plug 10. This improves in particular the sealing at high pressures exerted in the syringe. Indeed, a cylindrical contact zone between the syringe body and the zone coated with the piston plug 10 ensures the absence of micro-folds of the coating 135 and thus allows to have a constant contact sealing area between the coating 135 of the piston stopper and the syringe body. In particular, this coating 135 extends to a shoulder 139 of said sealing profile 130. This shoulder 139 is generated by the manufacturing process of the piston stopper of FIG. 1, as will be described in more detail below. 3 to 5. During the insertion of the piston plug 10 into a syringe body, the deformation profile 133 may deform radially, thereby allowing the sealing profile 130 of the end wall 13 to penetrate. more easily inside the syringe body. After insertion of said plug-piston 10 into the syringe body, the various sealing profiles, that is to say the sealing profile 130 of the front wall 13 and the sealing profiles 110 of the hollow cylindrical body 11 can slightly relax while remaining sufficiently constrained against the cylindrical wall of the syringe body to ensure a perfect seal. The presence of the deformation profile 133 in the frontal axial outer surface 131 of the front wall 13 facilitates this insertion. Indeed, the presence of the coating 135 stiffens the material and therefore generally makes its insertion more complicated. Providing a deformation profile makes it possible to compensate for the increase in friction associated with the ETFE coating, and thus makes it possible to ensure a more reliable and secure insertion of the coated piston stopper as described above. Likewise, the presence of the deformation profile 133 in the frontal axial external surface 131 of the front wall 13 of the piston with coating makes it possible to have a behavior identical to that of an uncoated piston, in particular with regard to the forces of activation and sliding of the piston during actuation. The internal volume 15 of the piston plug 10 may comprise a thread 115. This thread 115 may be continuous or discontinuous. In the variant of a discontinuous threading, several axial grooves, advantageously four, may be provided to interrupt said threading 115.
    [0010] Figures 3 to 5 illustrate a plug-piston manufacturing machine of Figure 1, with a first mold portion 201 which is the bottom portion in Figures 3 and 4 and a second portion of the mold 202 which is the upper portion. The first part of the mold 201 is used to form the hollow cylindrical body 11 and comprises for this purpose a core 200. This core 200 comprises an axial endpiece 210 which will define said internal volume 15 of said piston cap 10. This method of manufacturing the The piston stopper of FIG. 1 is complex because it requires several undercuts on the first mold part 201 and on the axial end piece 210 of the core 200, to form on the one hand the internal thread 115 and on the other hand the 110. This makes demolding more difficult. Figure 5 illustrates the step of cutting the plug-piston. It can be seen that because of the coating 135, the cut can not be made with tension of the fabric, which generates a cutting diameter slightly greater than that of the molded sealing profiles 110, and therefore said shoulder 139 visible on the Thus, the first sealing zone formed by the sealing profile 130 is formed at the cutting zone, which generates a non-smooth surface state, with consequent potential risks of infiltration and or sliding of the piston. Indeed, a piston having as a first sealing zone a cutting zone comprising micro-grooves (due to cutting) causes: - less good sealing performance (micro-passages for the liquid by the streaks), and a less good slip, because of the surface condition and the larger cutting diameter than the sealing profiles 110 produced by molding, because this cutting area can not be made with tension, because of the rigidity 135. In known manner, the piston-plug 10 may also be completely coated with silicone oil to promote its sliding, especially during its insertion into the syringe. Alternatively, if it is desired to remove this silicone oil, it is also possible to provide a parylene coating, also on the entire plug-piston. In this case, the ETFE film on the front surface of the piston may be treated to allow attachment of the parylene. According to the invention, the piston stopper is made by overmolding two parts. FIG. 2 illustrates such a plug-piston, and FIGS. 6 to 11 illustrate a method of manufacturing said plug-piston. For the sake of clarity, the elements of said piston cap and said method according to the invention which are similar to those of the prior art shown in FIGS. 1 and 3 to 5 comprise the same numerical references increased by 500.
    [0011] Thus, according to the invention, the piston-plug 510 has a first molded portion formed of a front wall 513 and a second portion overmolded on said first molded portion formed of a cylindrical body 511, preferably hollow. Separation line 700 illustrates this two-part constitution.
    [0012] If the cylindrical body 511 is hollow, it has an open rear axial side 512 and a front axial side which is closed by said front wall 513. Thus, this embodiment defines a piston plug 510 of generally cylindrical shape with an internal volume 515 one-eyed, that is to say, open on one side and closed on the other side. The front wall 513 defines a frontal axial outer surface 631 which is the surface that will be in contact with the fluid when the piston cap 510 is assembled into a syringe body (not shown) for containing such a fluid. This axial front external surface 631 is provided with a coating 635, advantageously a thin film made of ETFE (ethylene tetrafluoroethylene), in order to limit as much as possible the interactions between said fluid product and the material of said piston cap. Other types of suitable coatings are also conceivable, as regards the method of application of the coating as the material constituting said coating. This frontal axial outer surface 631 can be conical by defining an axial point 1810, as visible in the embodiment of FIG. 2, but it could also be flat and substantially perpendicular to the central axis of the piston stopper.
    [0013] The front wall 513 has a primary sealing profile 630 formed on its radially outer edge. The outer surface of the piston plug 510 further comprises at least one, preferably several secondary sealing profiles 610, which are generally in the form of radially projecting beads. Preferably, as shown in Figure 2, the outer surface of the piston plug 510 comprises two secondary sealing profiles 610 made in the form of radially projecting beads. In the example shown in Figure 2, one of the secondary sealing profiles 610 is formed on said front portion 513 and the other on said hollow cylindrical body 511, but alternatively the two secondary sealing profiles 610 could be formed on said hollow cylindrical body 511. Advantageously, said front axial outer surface 631 of said front wall 513 may comprise a deformation profile 633 which is adapted to deform to facilitate insertion of the piston plug 510 into a syringe body . This deformation profile may be disposed radially inside said primary sealing profile 630, that is to say that it is not necessarily arranged at the radially outer edge of said front wall 513. Advantageously, this deformation profile 633 can be produced in the form of a peripheral groove formed in said front axial axial surface 631. In the example shown in FIG. 2, this groove, before deformation, is substantially U-shaped, but it could obviously also have another shape, for example a V-shape, W or any other suitable form for radial deformation of the front wall 513 during the insertion of the piston-plug. Advantageously, said deformation profile 633 is of rounded shape, that is to say that it does not define a sharp angle in said front axial external surface 631 of said front wall 513. However, such sharp angles can generate areas of weakness of the coating 635, not only during the molding of the plug-piston where they can be torn generator, but also in use, where the coating 635 could crack or tear at said sharp angles, by example during the compression of the plug-piston during its introduction into the syringe, with consequent risks of discontinuity of said coating. Advantageously, said coating 635 extends not only on said front axial outer surface 631, but also at least partially on the outer cylindrical surface of said sealing profile 630. This makes it possible to guarantee the presence of a first cylindrical sealing zone between the inside of a syringe body and the coated portion of said primary sealing profile 630 of the piston-plug 510. This improves in particular the sealing at high pressures exerted in the syringe. Indeed, a cylindrical contact zone between the syringe body and the zone coated with the piston plug 510 ensures the absence of micro-folds of the coating 635 and thus makes it possible to have a constant contact sealing zone between the coating 635 of the cap-piston and the syringe body. During insertion of the plunger plug 510 into a syringe body, the deformation profile 633 may deform radially, which allows the primary sealing profile 630 of the front wall 513 to penetrate more easily within the body. syringe.
    [0014] After insertion of said piston plug 510 into the syringe body, the various sealing profiles, i.e. the primary sealing profile 630 and the secondary sealing profiles 610 can slightly relax while remaining sufficiently constrained against the cylindrical wall of the syringe body to ensure a perfect seal.
    [0015] The presence of the deformation profile 633 in the frontal axial outer surface 631 of the front wall 513 facilitates this insertion. Indeed, the presence of the coating 635 stiffens the material and therefore generally makes its insertion more complicated. Providing a deformation profile makes it possible to compensate for the increase in friction associated with the ETFE coating, and thus makes it possible to ensure a more reliable and reliable insertion of the coated piston plug as described above. Likewise, the presence of the deformation profile 633 in the frontal axial external surface 631 of the front wall 513 of the piston with coating makes it possible to have a behavior identical to that of an uncoated piston, in particular with regard to the forces of activation and sliding of the piston during actuation.
    [0016] The internal volume 515 of the piston plug 510 may comprise a threading 615. This threading 615 may be continuous or discontinuous. In the variant of a discontinuous threading, several axial grooves, advantageously four, may be provided to interrupt said threading 615. As a variant, the piston stopper may be solid, that is to say not have a hollow internal volume. . The piston plug 510 according to the invention, made in two overmoulded parts, has the particular advantage of being able to be formed from two different materials, having optimized properties. Thus, mechanical properties (hardness, elasticity, elongation) make it possible to optimize the functional properties of the piston (sliding, sealing, machine passage, etc.) and the chemical properties of the materials (extractables level, etc.). .) make it possible to use a material of high purity for the front wall 513 in contact with the film (1st molding step), and to combine it with another material with optimized functional properties (in the 2nd "molding step). , the cylindrical body 511 and the front wall 513 are each made of a rubber material, comprising for example one or more synthetic polymeric elastomers, such as butyl rubber (isobutylene and isoprene copolymer), chlorobutyl rubber (copolymer of isobutylene-isoprene derived from the reaction of a butyl rubber with chlorine), bromobutyl rubber (isobutyleneisoprene copolymer derived from the reaction of butyl rubber with bromine), copolymers of isobutylene rubber and para-methylstyrene, isoprene rubber (synthetic polyisoprene), SBR rubber (styrene-butadiene copolymer), NBR (butadiene acrylonitrile copolymer), EPDM rubber (ethylene-propylene-diene terpolymer).
    [0017] These materials can be associated with different accelerators and / or charges to obtain the desired characteristics. According to the invention, said cylindrical body 511 and said front wall 513 are made of different materials. The rubbers can be different. Alternatively, the cylindrical body 511 may advantageously be made of a material that can be composed of the same rubber bases as those of said front wall 513, but associated with one or more charges and / or accelerators in their quantities and / or compositions.
    [0018] Figures 6 to 11 illustrate the method of manufacturing the plug-piston of Figure 2, according to an advantageous embodiment of the present invention. Figure 6 shows the molding of the front wall 513 together with the coating 635, made in a first mold conventionally comprising. two parts of molds 301, 302. The mold is easy, since said mold has no undercut. FIG. 7 illustrates the cutting of said molded front wall, in particular by means of a punch or a die 350. FIG. 8 represents the front wall 513 after molding and cutting, and before overmoulding of the hollow cylindrical body 511. 9 and 10 illustrate the overmolding of the hollow cylindrical body 511 on the front wall 513. The front wall 513 is disposed in a first mold portion 401 of a second mold and said hollow cylindrical body 511 is overmolded around a core 410. a second portion 402 of said second mold. Said core 410 defines said internal volume 515, and it therefore advantageously comprises an external thread which will define the internal threading 615 of said piston plug 510. The demolding is simplified: extraction of the core (for example by deformation of the molded material) by displacement of the upper part of the mold, then demolding the web (against-bodies defining the secondary sealing profiles 610 can be demolded by radial deformation of the plug-piston inwardly, thanks to the vacuum left by the extraction of the core. during this overmolding step, the cutting area of said molded front wall, generated by the cutting step shown in FIG. 7, will be re-shaped in said second mold, and hence the diameter of this zone of The fact of placing said molded front wall in a second mold thus makes it possible to avoid a disadvantage of the prior art such that As previously described, Fig. 11 shows the final cutting step. Here, the cut can be conventionally made on the back of the piston stopper, at the open rear axial side 512, as when the piston stopper has no coating 635 on its axial front external surface 631. This allows to have a canvas stretched at the time of cutting, thereby generating a radial withdrawal of this area once cut relative to the secondary sealing profiles 610. This cutting step is conventionally performed by means of a punch or a matrix 450.
    [0019] In a known manner, the piston stopper 510 may also be completely coated with silicone oil to promote its sliding, in particular during its insertion into the syringe. Alternatively, if it is desired to remove this silicone oil, it is also possible to provide a parylene coating, also on the entire plug-piston. In this case, the ETFE film on the front surface of the piston may be treated to allow attachment of the parylene. Although the present invention has been described with reference to a particular embodiment, it is understood that the present invention is not limited by it but that on the contrary the person skilled in the art can make any useful modifications without depart from the scope of the present invention as defined by the appended claims.
    权利要求:
    Claims (15)
    [0001]
    CLAIMS1.- Piston plug (510) having a cylindrical body (511) having a front axial side closed by a front wall (513), said piston cap (510) having an outer surface provided with at least one profile of secondary seal (610), said front wall (513) having a front axial outer surface (631) provided with a coating (635), advantageously an ethylene tetrafluoroethylene film, said front wall (513) having on its radially outer edge a primary sealing profile (630), characterized in that said front wall (513) and said cylindrical body (511) are made of different materials, said hollow cylindrical body (511) being overmoulded on said front wall (513).
    [0002]
    2. A plunger stopper according to claim 1, wherein said cylindrical body (511) is made of a rubber material, comprising one or more synthetic polymeric elastomers, such as butyl rubber, chlorobutyl rubber, bromobutyl rubber, copolymers of isobutylene rubber and parmethylstyrene, isoprene rubber, SBR rubber, NBR, EPDM.
    [0003]
    3.- piston stopper according to claim 2, wherein said material is associated with at least one accelerator and / or load.
    [0004]
    4. A plunger stopper according to any one of the preceding claims, wherein said front wall (513) is made of a rubber material, comprising by one or more synthetic polymeric elastomers, such as butyl rubber, chlorobutyl rubber, bromobutyl rubber, copolymers of isobutylene and para-methylstyrene rubber, isoprene rubber, SBR rubber, NBR, EPDM.
    [0005]
    5.- piston stopper according to claim 4, wherein said material is associated with at least one accelerator and / or load.
    [0006]
    The piston stopper according to claims 3 and 5, wherein said at least one accelerator and / or load of said cylindrical body (511) is different in quantity and / or composition from said at least one accelerator and / or charge. said front wall (513).
    [0007]
    7. A plunger plug according to any one of the preceding claims, wherein said cylindrical body (511) comprises a secondary sealing profile (610) and said front wall (513) comprises a secondary sealing profile (610). .
    [0008]
    The plunger plug of claim 7, wherein said secondary sealing profiles (610) are radially projecting beads.
    [0009]
    9. A plunger plug according to any one of the preceding claims, wherein said front axial outer surface (631) of said front wall (513) comprises a deformation profile (633) disposed radially inside said profile. primary seal (630) of said front wall (513), said deformation profile (633) being adapted to deform radially to facilitate insertion and / or sliding of said piston cap (510) into a syringe body.
    [0010]
    The plunger plug according to claim 9, wherein said deformation profile (633) is in the form of a circumferential groove in said front axial outer surface (631) of said end wall (513), said groove preferably being V-shaped or U-shaped.
    [0011]
    The plunger plug of any preceding claim, wherein said cylindrical body (511) is hollow and defines an internal volume (515), said hollow cylindrical body (511) having an open back axial side (512). axially opposite said front axial side closed by said front wall (513).
    [0012]
    12. The plunger stopper according to claim 11, wherein said internal volume (515) cooperates with an actuating member of a syringe device.
    [0013]
    13. A plunger stopper according to claim 12, wherein said hollow cylindrical body (511) has on its internal surface a thread (615) adapted to be screwed onto a thread of said actuating member.
    [0014]
    The plunger plug of any preceding claim, wherein said front axial outer surface (631) is tapered and defines a central axial tip (1810).
    [0015]
    15. A plunger stopper according to any one of the preceding claims, wherein said deformation profile (633) is of rounded shape, so that said axial front external surface (631) of said front wall (513) is devoid of sharp angles.
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    同族专利:
    公开号 | 公开日
    TW201636063A|2016-10-16|
    JP2018507027A|2018-03-15|
    EP3250269A1|2017-12-06|
    CN107206182B|2020-03-31|
    CN107206182A|2017-09-26|
    IL253019D0|2017-08-31|
    FR3032123B1|2021-04-23|
    KR20170109593A|2017-09-29|
    TWI626064B|2018-06-11|
    US20170368264A1|2017-12-28|
    WO2016120565A1|2016-08-04|
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    US20140062036A1|2012-08-30|2014-03-06|Sumitomo Rubber Industries, Ltd.|Laminated gasket|
    EP2803378A1|2013-05-15|2014-11-19|Sumitomo Rubber Industries, Ltd.|Gasket for syringe|
    US5397313A|1994-01-27|1995-03-14|The Kendall Company|Low friction syringe|
    EP1180377A1|2000-08-16|2002-02-20|Schering Aktiengesellschaft|Syringe with piston|
    DE10122959A1|2001-05-11|2002-11-21|West Pharm Serv Drug Res Ltd|Method for producing a piston for a pharmaceutical syringe or a similar item includes a step in which surplus of the inert foil cap on the piston body is separated in a punching unit|
    US6942638B1|2002-05-30|2005-09-13|Kerry Quinn|Needleless injector and ampule system|
    JP4635175B2|2003-06-24|2011-02-23|日本メジフィジックス株式会社|Highly sealed syringe filled with chemical liquid, gasket, and manufacturing method of syringe filled with chemical liquid|
    DE102004040969A1|2004-08-24|2006-03-02|Schering Ag|Piston for a syringe and syringe|
    JP2006181027A|2004-12-27|2006-07-13|Daikyo Seiko Ltd|Piston for syringe|
    US8740856B2|2007-06-04|2014-06-03|Becton, Dickinson And Company|Stoppers used in pre-filled syringes|
    EP2773397B1|2011-11-02|2022-02-23|Sanofi-Aventis Deutschland GmbH|Piston for a cartridge for use in a drug delivery device|
    JP6215546B2|2013-03-21|2017-10-18|住友ゴム工業株式会社|Gasket for prefilled syringe|
    FR3011472B1|2013-10-09|2017-09-01|Aptar Stelmi Sas|CAP-PISTON AND SYRINGE DEVICE COMPRISING SUCH A PLUG-PISTON|JP6402288B1|2017-08-09|2018-10-10|住友ゴム工業株式会社|Gasket for syringe|
    WO2019031028A1|2017-08-09|2019-02-14|住友ゴム工業株式会社|Syringe gasket|
    US20200330690A1|2018-05-15|2020-10-22|Becton, Dickinson And Company|Syringe Plunger Stopper for High Dose Accuracy Drug Delivery|
    法律状态:
    2016-01-27| PLFP| Fee payment|Year of fee payment: 2 |
    2016-08-05| PLSC| Publication of the preliminary search report|Effective date: 20160805 |
    2017-01-25| PLFP| Fee payment|Year of fee payment: 3 |
    2018-01-29| PLFP| Fee payment|Year of fee payment: 4 |
    2020-01-28| PLFP| Fee payment|Year of fee payment: 6 |
    2021-01-26| PLFP| Fee payment|Year of fee payment: 7 |
    2022-01-27| PLFP| Fee payment|Year of fee payment: 8 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1550678A|FR3032123B1|2015-01-29|2015-01-29|SYRINGE PLUG-PLUG.|FR1550678A| FR3032123B1|2015-01-29|2015-01-29|SYRINGE PLUG-PLUG.|
    JP2017540257A| JP2018507027A|2015-01-29|2016-01-28|Stopper / piston member for syringe|
    US15/546,307| US20170368264A1|2015-01-29|2016-01-28|Syringe plunger-stopper|
    KR1020177023616A| KR20170109593A|2015-01-29|2016-01-28|Piston-stopper for syringe|
    CN201680007380.9A| CN107206182B|2015-01-29|2016-01-28|Stopper-piston for syringe|
    EP16707843.5A| EP3250269A1|2015-01-29|2016-01-28|Syringe plunger-stopper.|
    PCT/FR2016/050173| WO2016120565A1|2015-01-29|2016-01-28|Syringe plunger-stopper.|
    TW105102801A| TWI626064B|2015-01-29|2016-01-29|A syringe piston|
    IL253019A| IL253019D0|2015-01-29|2017-06-19|A syringe stopper/piston|
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